Compound Reduces Neurodegeneration in Mouse Model of MS

Researchers from Virginia Commonwealth University and the University of Illinois at Chicago have identified a compound that is able to reduce neurodegeneration in a mouse model of multiple sclerosis. The molecule, lanthionine ketimine ethyl-ester (LKE), has been previously shown to reduce neurotoxicity and promote the generation of new neurons.

In this study, mice were given a chronic version of MS and then were treated with LKE via their food. Over a 4 week period, mice treated with LKE showed a significant improvement in clinical signs compared to those who did not receive the compound. This included less neurodegeneration in the optic nerve and spinal cord, as well as an increased percentage of nerves with thicker myelin. Considering the potential for LKE to reduce neurodegeneration in a chronic animal model of MS, the authors suggest a possible role in the treatment of progressive MS. Larger, well-controlled studies in people with MS will need to be conducted before the reality of this is known.